Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16309223 | 1.00 | HCRTR1 (0.49) | HCRTR1HCRTR2MEN1KMT2AALDH1A1 | |
| SCHEMBL10173557 | 0.96 | HCRTR1 (0.53) | HCRTR1HCRTR2ALDH1A1CYP2C9TSHR | |
| SCHEMBL17044979 | 0.95 | HCRTR1 (0.49) | HCRTR1HCRTR2ALDH1A1CYP2C9TSHR | |
| SCHEMBL16188355 | 0.92 | HCRTR1 (0.48) | HCRTR1HCRTR2ALDH1A1CYP2C9TSHR | |
| SCHEMBL10223631 | 0.90 | HCRTR1 (0.50) | HCRTR1HCRTR2ALDH1A1TSHRNPSR1 | |
| SCHEMBL10224109 | 0.90 | HCRTR1 (0.50) | HCRTR1HCRTR2ALDH1A1TSHRNPSR1 | |
| SCHEMBL894834 | 0.90 | HCRTR1 (0.50) | HCRTR1HCRTR2ALDH1A1TSHRNPSR1 | |
| SCHEMBL17613191 | 0.89 | HCRTR1 (0.56) | HCRTR1HCRTR2ALDH1A1CYP2C9LMNA | |
| SCHEMBL22352068 | 0.89 | HCRTR1 (0.49) | HCRTR1HCRTR2ALDH1A1TSHRNPSR1 | |
| SCHEMBL10173644 | 0.89 | HCRTR1 (0.50) | HCRTR1HCRTR2ALDH1A1CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150246917-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP. (US) | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246917-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | HCRTR1 4044/4885HCRTR2 4504/4885MEN1 4685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.