SCHEMBL17613191

SCHEMBL17613191

O=C(Nc1ccc(-c2cc3ccccc3[nH]2)cc1)[C@@H]1CCCN1C(=O)Cc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 5/20 0.56
HCRTR2 O43614 5/20 0.56
SLC2A1 P11166 1/20 0.51
ALDH1A1 P00352 3/20 0.48
ITGB1 P05556 4/20 0.46
ITGA4 P13612 4/20 0.46
KDM4E B2RXH2 1/20 0.45
LMNA P02545 1/20 0.45
HSD17B10 Q99714 1/20 0.44
USP2 O75604 1/20 0.44
CRHBP P24387 1/20 0.44
CRHR2 Q13324 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL895907 0.94 HCRTR1 (0.53) HCRTR1HCRTR2SLC2A1ALDH1A1ITGB1
SCHEMBL10173557 0.94 HCRTR1 (0.53) HCRTR1HCRTR2SLC2A1ALDH1A1ITGB1
SCHEMBL10173435 0.90 HCRTR1 (0.50) HCRTR1HCRTR2SLC2A1ALDH1A1ITGB1
SCHEMBL10173644 0.90 HCRTR1 (0.50) HCRTR1HCRTR2SLC2A1ALDH1A1ITGB1
SCHEMBL17613192 0.90 HCRTR1 (0.50) HCRTR1HCRTR2SLC2A1ALDH1A1ITGB1
SCHEMBL16309223 0.89 HCRTR1 (0.49) HCRTR1HCRTR2SLC2A1ALDH1A1ITGB1
SCHEMBL17044979 0.89 HCRTR1 (0.49) HCRTR1HCRTR2SLC2A1ALDH1A1ITGB1
SCHEMBL17044953 0.89 HCRTR1 (0.49) HCRTR1HCRTR2SLC2A1ALDH1A1ITGB1
SCHEMBL22352068 0.89 HCRTR1 (0.49) HCRTR1HCRTR2SLC2A1ALDH1A1ITGB1
SCHEMBL16188355 0.88 HCRTR1 (0.48) HCRTR1HCRTR2SLC2A1ALDH1A1ITGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2410844-B1 INHIBITORS OF HEPATITIS C VIRUS REPLICATION MERCK SHARP & DOHME (US) 2016-03-23 EP disclosed