Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 6/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.41 |
| ▸ | ARG1 | P05089 | 1/20 | 0.39 |
| ▸ | ARG2 | P78540 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15620629 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2HIF1ACES1FDPSCYP1A2 | |
| SCHEMBL419615 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2HIF1ACES1FDPSCYP1A2 | |
| SCHEMBL9557132 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2HIF1AFDPSCYP1A2CYP2C9 | |
| SCHEMBL28979783 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2HIF1AFDPSCYP1A2CYP2C9 | |
| SCHEMBL7023498 | 0.77 | KMT2A (0.52) | SMN1; SMN2HIF1AFDPSCYP1A2CYP2C9 | |
| SCHEMBL3730337 | 0.77 | SMN1; SMN2 (0.53) | SMN1; SMN2HIF1ACES1FDPSCYP1A2 | |
| SCHEMBL7300860 | 0.76 | SLC13A5 (0.56) | SMN1; SMN2HIF1AFDPSCYP1A2CYP2C9 | |
| SCHEMBL7908936 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2HIF1ACES1FDPSCYP1A2 | |
| SCHEMBL10029155 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2HIF1ACES1FDPSCYP1A2 | |
| SCHEMBL7908766 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2HIF1ACES1FDPSCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249157-B2 | Tricyclic heterocycle compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150246930-A1 | TRICYCLIC HETEROCYCLE COMPOUNDS | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246930-A1 | TRICYCLIC HETEROCYCLE COMPOUNDS | RCOR3, NR4A3, NCOA3 | SMN1; SMN2 4339/4885HIF1A 1536/4885CES1 1120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.