Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.73 |
| ▸ | HTR2A | P28223 | 4/20 | 0.65 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR1E | P28566 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28837438 | 0.86 | HTR2A (0.71) | GPR84HTR2ATRPM8SLC6A4HTR1A | |
| SCHEMBL2404863 | 0.85 | GPR84 (0.73) | GPR84HTR2ATRPM8SLC6A4HTR1A | |
| SCHEMBL18383117 | 0.85 | GPR84 (1.00) | GPR84HTR2ATRPM8SLC6A4HTR1A | |
| SCHEMBL949791 | 0.83 | GPR84 (0.76) | GPR84HTR2ATRPM8SLC6A4HTR1A | |
| SCHEMBL892446 | 0.81 | HTR2A (0.75) | GPR84HTR2ATRPM8SLC6A4HTR1A | |
| SCHEMBL26498347 | 0.81 | GPR84 (0.73) | GPR84HTR2ATRPM8SLC6A4HTR1A | |
| SCHEMBL7599108 | 0.81 | GPR84 (0.73) | GPR84HTR2ATRPM8SLC6A4HTR1A | |
| SCHEMBL31567582 | 0.81 | GPR84 (0.73) | GPR84HTR2ATRPM8SLC6A4HTR1A | |
| SCHEMBL10119751 | 0.81 | GPR84 (0.73) | GPR84HTR2ATRPM8SLC6A4HTR1A | |
| SCHEMBL15676249 | 0.81 | HTR2A (0.69) | GPR84HTR2ATRPM8SLC6A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440550-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-04-18 | — | — | EP | disclosed |