Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17048401 | 0.92 | PTGS1 (0.55) | PTGS1PTGS2POLBNPC1RAB9A | |
| Cyclopentanone SCHEMBL17048275 | 0.82 | PTGS1 (0.47) | PTGS1PTGS2POLBKMT2AMAPT | |
| SCHEMBL18589112 | 0.77 | PTGS1 (0.51) | PTGS1PTGS2POLBNPC1RAB9A | |
| SCHEMBL18589107 | 0.76 | PTGS1 (0.50) | PTGS1PTGS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8167269 | 0.75 | ALOX15 (0.44) | PTGS1PTGS2POLBNPC1RAB9A | |
| SCHEMBL18589111 | 0.74 | PTGS1 (0.48) | PTGS1PTGS2POLBNPC1RAB9A | |
| SCHEMBL24752789 | 0.71 | CRBN (0.63) | — | |
| SCHEMBL17048156 | 0.71 | KMT2A (0.55) | PTGS1PTGS2POLBNPC1RAB9A | |
| SCHEMBL17048402 | 0.70 | PTGS1 (0.51) | PTGS1PTGS2POLBNPC1RAB9A | |
| SCHEMBL18589050 | 0.70 | PTGS1 (0.43) | PTGS1PTGS2POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3110815-A1 | INDOLOQUINOLONE COMPOUNDS AS ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITORS | Jiangsu Ascentage Biomed Development Inc. (CN) | 2017-01-04 | — | — | EP | disclosed |
| WO-2015127629-A1 | INDOLOQUINOLONE COMPOUNDS AS ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITORS | JIANGSU ASCENTAGE BIOMED DEVELOPMENT INC. (CN) | 2015-09-03 | — | — | WO | disclosed |