Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25981632 | 0.88 | MEN1 (0.33) | MEN1CYP2C9KMT2A | |
| SCHEMBL10996234 | 0.85 | MEN1 (0.39) | MEN1CYP2C9KMT2AFFAR3 | |
| SCHEMBL769660 | 0.80 | — | — | |
| SCHEMBL27712711 | 0.77 | NPSR1 (0.34) | MEN1CYP2C9KMT2AFFAR3 | |
| SCHEMBL4291856 | 0.76 | MEN1 (0.32) | MEN1CYP2C9KMT2AFFAR3 | |
| SCHEMBL10586224 | 0.75 | FFAR3 (0.39) | FFAR3 | |
| SCHEMBL11986245 | 0.75 | FFAR3 (0.39) | FFAR3 | |
| SCHEMBL15549626 | 0.74 | FFAR3 (0.33) | MEN1KMT2AFFAR3 | |
| SCHEMBL13736831 | 0.73 | CYP2C19 (0.39) | FFAR3 | |
| SCHEMBL20483615 | 0.72 | POLB (0.40) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452448-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |
| EP-3110810-A1 | PYRAZOLE AMIDE DERIVATIVE | Teijin Pharma Limited (JP) | 2017-01-04 | — | — | EP | disclosed |
| WO-2015129926-A1 | PYRAZOLE AMIDE DERIVATIVE | TEIJIN PHARMA LIMITED (JP) | 2015-09-03 | — | — | WO | disclosed |