SCHEMBL17049264

SCHEMBL17049264

CC(C)OC(=O)C1=CCCC1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 2/20 0.50
HDAC2 Q92769 2/20 0.50
HDAC8 Q9BY41 2/20 0.50
HDAC6 Q9UBN7 2/20 0.50
HDAC3 O15379 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC7 Q8WUI4 1/20 0.50
HDAC5 Q9UQL6 1/20 0.50
CA12 O43570 6/20 0.40
CA1 P00915 6/20 0.40
CA2 P00918 6/20 0.40
CA7 P43166 6/20 0.40
CA9 Q16790 6/20 0.40
CA14 Q9ULX7 6/20 0.40
SLC6A2 P23975 1/20 0.38
SLC6A3 Q01959 1/20 0.38
HSD17B10 Q99714 2/20 0.37
ALOX15 P16050 1/20 0.37
PDCD1 Q15116 1/20 0.37
CD274 Q9NZQ7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5972221 0.86 CA12 (0.44) CA12CA1CA2CA7CA9
SCHEMBL44118 0.78
Ammonia Solution, Strong SCHEMBL27732707 0.78 HDAC4 (0.42) HDAC4HDAC2HDAC8HDAC6HDAC3
SCHEMBL4846219 0.76 HDAC4 (0.41) HDAC4HDAC2HDAC8HDAC6HDAC3
SCHEMBL818926 0.76 CA12 (0.42) CA12CA1CA2CA7CA9
Water SCHEMBL28045945 0.76 HDAC4 (0.53) HDAC4HDAC2HDAC8HDAC6HDAC3
SCHEMBL8679124 0.75 HDAC4 (0.41) HDAC4HDAC2HDAC8HDAC6HDAC3
SCHEMBL16850492 0.74 HDAC2 (0.62) HDAC4HDAC2HDAC8HDAC6HDAC3
SCHEMBL340678 0.74 HDAC4 (0.47) HDAC4HDAC2HDAC8HDAC6HDAC3
SCHEMBL5433945 0.74 TSHR (0.40) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015131100-A1 LIGAND-CONTROLLED C(SP3)-H ARYLATION AND OLEFINATION IN SYNTHESIS OF UNNATURAL CHIRAL ALPHA AMINO ACIDS THE SCRIPPS RESEARCH INSTITUTE (US) 2015-09-03 WO disclosed