Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.60 |
| ▸ | WNT3A | P56704 | 5/20 | 0.52 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705021 | 0.94 | KARS1 (0.61) | KARS1WNT3ATBK1GPR119 | |
| SCHEMBL901656 | 0.91 | KARS1 (0.63) | KARS1WNT3A | |
| SCHEMBL901379 | 0.91 | KARS1 (0.64) | KARS1WNT3ATBK1GPR119 | |
| SCHEMBL1704964 | 0.90 | KARS1 (0.74) | KARS1WNT3ATBK1GPR119 | |
| SCHEMBL1704400 | 0.89 | KARS1 (0.63) | KARS1WNT3A | |
| SCHEMBL1705170 | 0.89 | KARS1 (0.56) | KARS1WNT3ATBK1 | |
| SCHEMBL1704420 | 0.88 | KARS1 (0.77) | KARS1 | |
| SCHEMBL1705168 | 0.88 | KARS1 (0.56) | KARS1WNT3ATBK1 | |
| SCHEMBL901426 | 0.87 | KARS1 (0.61) | KARS1WNT3ATBK1GPR119 | |
| SCHEMBL1705215 | 0.86 | KARS1 (0.62) | KARS1WNT3ATBK1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |