Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | JAK3 | P52333 | 5/20 | 0.48 |
| ▸ | LCK | P06239 | 4/20 | 0.48 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704970 | 0.90 | BTK (0.51) | BTKSYKEGFRJAK3LCK | |
| SCHEMBL1705522 | 0.90 | BTK (0.51) | BTKSYKEGFRJAK3LCK | |
| SCHEMBL1705612 | 0.90 | BTK (0.52) | BTKSYKEGFRJAK3LCK | |
| SCHEMBL1705199 | 0.86 | BTK (0.49) | BTKSYKEGFRJAK3LCK | |
| SCHEMBL16786050 | 0.79 | EGFR (0.72) | BTKSYKEGFRJAK3LCK | |
| SCHEMBL16798397 | 0.79 | EGFR (0.58) | BTKEGFRJAK3LCK | |
| SCHEMBL16798395 | 0.79 | EGFR (0.58) | BTKEGFRJAK3LCK | |
| Hydrochloric Acid SCHEMBL16763680 | 0.78 | EGFR (0.71) | BTKSYKEGFRJAK3LCK | |
| Hydrochloric Acid SCHEMBL16763678 | 0.78 | EGFR (0.71) | BTKSYKEGFRJAK3LCK | |
| SCHEMBL1705058 | 0.78 | BTK (0.46) | BTKSYKEGFRJAK3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440204-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | Bristol-Myers Squibb Company (US) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010144647-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-16 | — | — | WO | disclosed |