Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.62 |
| ▸ | SIK2 | Q9H0K1 | 12/20 | 0.62 |
| ▸ | SIK3 | Q9Y2K2 | 12/20 | 0.62 |
| ▸ | SIK1 | P57059 | 10/20 | 0.62 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 0.62 |
| ▸ | SRC | P12931 | 6/20 | 0.59 |
| ▸ | BCR | P11274 | 4/20 | 0.59 |
| ▸ | KIT | P10721 | 3/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | FYN | P06241 | 2/20 | 0.59 |
| ▸ | CSF1R | P07333 | 2/20 | 0.59 |
| ▸ | YES1 | P07947 | 2/20 | 0.59 |
| ▸ | LYN | P07948 | 2/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | HCK | P08631 | 2/20 | 0.59 |
| ▸ | BRAF | P15056 | 2/20 | 0.59 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30944822 | 0.82 | ABL1 (0.65) | ABL1SIK2SIK3SIK1PKMYT1 | |
| SCHEMBL29381575 | 0.81 | ABL1 (0.65) | ABL1SIK2SIK3SIK1PKMYT1 | |
| SCHEMBL1704785 | 0.81 | ABL1 (0.65) | ABL1SIK2SIK3SIK1PKMYT1 | |
| SCHEMBL30197903 | 0.81 | ABL1 (0.65) | ABL1SIK2SIK3SIK1PKMYT1 | |
| SCHEMBL1704413 | 0.81 | ABL1 (0.64) | ABL1SIK2SIK3SIK1PKMYT1 | |
| SCHEMBL28548985 | 0.79 | PKMYT1 (0.88) | ABL1SIK2SIK3SIK1PKMYT1 | |
| SCHEMBL20537284 | 0.79 | PKMYT1 (0.85) | ABL1SIK2SIK3SIK1PKMYT1 | |
| SCHEMBL20537134 | 0.78 | ABL1 (0.79) | ABL1SIK2SIK3SIK1PKMYT1 | |
| SCHEMBL13378598 | 0.78 | ABL1 (0.89) | ABL1SIK2SIK3SIK1PKMYT1 | |
| SCHEMBL31634945 | 0.78 | ABL1 (0.89) | ABL1SIK2SIK3SIK1PKMYT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109690-B9 | EPH-B4 SPECIFIC SIRNA FOR REDUCING EPO-INDUCED TUMOR CELL GROWTH DURING ANEMIA TREATMENT IN CANCER PATIENTS, TISSUE PROTECTIVE ERYTHROPOIETIN RECEPTOR (NEPOR) AND METHODS OF USE. | MOLECULAR HEALTH GMBH (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2109690-B1 | EPH-B4 SPECIFIC SIRNA FOR REDUCING EPO-INDUCED TUMOR CELL GROWTH DURING ANEMIA TREATMENT IN CANCER PATIENTS, TISSUE PROTECTIVE ERYTHROPOIETIN RECEPTOR (NEPOR) AND METHODS OF USE. | MOLECULAR HEALTH GMBH (DE) | 2012-04-18 | — | — | EP | disclosed |