Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | KCNK3 | O14649 | 5/20 | 0.64 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.55 |
| ▸ | RHOC | P08134 | 1/20 | 0.52 |
| ▸ | RHOA | P61586 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15604709 | 0.88 | MEN1 (0.82) | MEN1KMT2ARAB9AHTTKCNK3 | |
| SCHEMBL12764063 | 0.82 | MEN1 (1.00) | MEN1KMT2ARAB9AHTTKCNK3 | |
| SCHEMBL17052993 | 0.82 | MEN1 (0.72) | MEN1KMT2ARAB9AHTTKCNK3 | |
| SCHEMBL12764058 | 0.82 | MEN1 (0.79) | MEN1KMT2ARAB9AHTTKCNK3 | |
| SCHEMBL18893144 | 0.77 | RXFP1 (0.74) | RXFP1 | |
| SCHEMBL2908619 | 0.77 | MEN1 (0.89) | MEN1KMT2ARAB9AHTTKCNK3 | |
| SCHEMBL15847043 | 0.77 | KCNK3 (0.92) | MEN1KMT2ARAB9AHTTKCNK3 | |
| SCHEMBL12764066 | 0.76 | KCNK3 (0.70) | MEN1KMT2ARAB9AHTTKCNK3 | |
| SCHEMBL17050937 | 0.75 | KCNK3 (0.67) | MEN1KMT2ARAB9AHTTKCNK3 | |
| SCHEMBL15676738 | 0.75 | MEN1 (0.74) | MEN1KMT2ARAB9AHTTKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394261-B2 | Aryl amine substituted pyrimidine and quinazoline and their use as anticancer drugs | NATIONAL YANG-MING UNIVERSITY (TW) | 2016-07-19 | — | — | US | disclosed |
| US-20150246891-A1 | ARYL AMINE SUBSTITUTED PYRIMIDINE AND QUINAZOLINE AND THEIR USE AS ANTICANCER DRUGS | NATIONAL TAIWAN UNIVERSITY (TW) | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246891-A1 | ARYL AMINE SUBSTITUTED PYRIMIDINE AND QUINAZOLINE AND THEIR USE AS ANTICANCER DRUGS | EGFR, ERBB4, ERBB2 | MEN1 3727/4885KMT2A 2105/4885RAB9A 496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.