Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.72 |
| ▸ | KCNK3 | O14649 | 11/20 | 0.68 |
| ▸ | KCNK9 | Q9NPC2 | 9/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15676738 | 0.87 | MEN1 (0.74) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL17664548 | 0.87 | NPC1 (0.59) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL4253897 | 0.85 | KCNK3 (0.93) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL1696311 | 0.84 | MEN1 (0.70) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL1690508 | 0.83 | MEN1 (0.68) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL21377635 | 0.82 | KCNK3 (0.77) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL17052865 | 0.82 | MEN1 (0.69) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL12764067 | 0.81 | KCNK3 (0.91) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL18718185 | 0.80 | MEN1 (0.63) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL13026980 | 0.80 | KCNK3 (0.72) | MEN1KMT2ARXFP1KCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394261-B2 | Aryl amine substituted pyrimidine and quinazoline and their use as anticancer drugs | NATIONAL YANG-MING UNIVERSITY (TW) | 2016-07-19 | — | — | US | disclosed |
| US-20150246891-A1 | ARYL AMINE SUBSTITUTED PYRIMIDINE AND QUINAZOLINE AND THEIR USE AS ANTICANCER DRUGS | NATIONAL TAIWAN UNIVERSITY (TW) | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246891-A1 | ARYL AMINE SUBSTITUTED PYRIMIDINE AND QUINAZOLINE AND THEIR USE AS ANTICANCER DRUGS | EGFR, ERBB4, ERBB2 | MEN1 3727/4885KMT2A 2105/4885RXFP1 3793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.