Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.63 |
| ▸ | MTOR | P42345 | 4/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.44 |
| ▸ | ATR | Q13535 | 8/20 | 0.44 |
| ▸ | PDCD1 | Q15116 | 8/20 | 0.44 |
| ▸ | ATRIP | Q8WXE1 | 8/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705895 | 0.91 | PIK3CA (0.68) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL1705852 | 0.90 | PIK3CA (0.50) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL1706192 | 0.89 | PIK3CA (0.74) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL3597171 | 0.85 | PIK3CA (0.79) | PIK3CAPIK3CDMTOR | |
| SCHEMBL739797 | 0.83 | PIK3CA (0.78) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL10266969 | 0.83 | PIK3CA (0.78) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL3597731 | 0.82 | PIK3CA (0.77) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3598541 | 0.81 | PIK3CA (0.78) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL3608272 | 0.81 | PIK3CA (0.64) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL3592644 | 0.81 | PIK3CA (0.75) | PIK3CAPIK3CDMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176238-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2012-04-18 | — | — | EP | claimed |