Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.74 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.74 |
| ▸ | MTOR | P42345 | 8/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | ATR | Q13535 | 2/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.47 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705895 | 0.91 | PIK3CA (0.68) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL1706152 | 0.91 | PIK3CA (0.61) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL1705779 | 0.89 | PIK3CA (0.63) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL3595596 | 0.85 | PIK3CA (1.00) | PIK3CAPIK3CDMTOR | |
| SCHEMBL738603 | 0.83 | PIK3CA (0.85) | PIK3CAPIK3CDMTOR | |
| SCHEMBL1705348 | 0.83 | PIK3CA (0.57) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3598541 | 0.81 | PIK3CA (0.78) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL3602962 | 0.81 | PIK3CA (0.80) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL3601773 | 0.80 | PIK3CA (0.88) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3604038 | 0.80 | PIK3CA (0.81) | PIK3CAPIK3CDMTORCHEK1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176238-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2012-04-18 | — | — | EP | claimed |