Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11944447 | 0.86 | POLB (0.33) | CA12CA1CA2CA9SLC2A1 | |
| SCHEMBL11944433 | 0.84 | POLB (0.33) | CA12CA1CA2CA9 | |
| SCHEMBL11944548 | 0.81 | MAPT (0.35) | CA12CA1CA2CA9 | |
| SCHEMBL17057937 | 0.81 | — | — | |
| SCHEMBL17057942 | 0.79 | POLB (0.42) | SLC2A1SLC2A3MCHR1 | |
| SCHEMBL17058415 | 0.77 | SLC2A1 (0.37) | SLC2A1SLC2A3MCHR1 | |
| SCHEMBL11945850 | 0.77 | POLB (0.37) | CA12CA1CA2CA9SLC2A1 | |
| SCHEMBL11945849 | 0.77 | POLB (0.37) | CA12CA1CA2CA9SLC2A1 | |
| SCHEMBL17057800 | 0.77 | SLC2A1 (0.31) | SLC2A1SLC2A3 | |
| SCHEMBL17058024 | 0.76 | SLC2A1 (0.33) | SLC2A1SLC2A3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |