Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.36 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058415 | 0.90 | SLC2A1 (0.37) | POLBSMN1; SMN2LMNAKMT2ASLC2A1 | |
| SCHEMBL11945844 | 0.89 | ALDH1A1 (0.46) | POLBSMN1; SMN2LMNAKMT2ASLC2A1 | |
| SCHEMBL11945843 | 0.89 | ALDH1A1 (0.46) | POLBSMN1; SMN2LMNAKMT2ASLC2A1 | |
| SCHEMBL17058083 | 0.88 | HTR1A (0.35) | POLBSMN1; SMN2LMNAKMT2ASLC2A1 | |
| SCHEMBL17058078 | 0.88 | HTR1A (0.35) | POLBSMN1; SMN2LMNAKMT2ASLC2A1 | |
| SCHEMBL14899749 | 0.88 | SMN1; SMN2 (0.45) | POLBSMN1; SMN2LMNAKMT2ASLC2A1 | |
| SCHEMBL11944360 | 0.87 | CYP3A4 (0.38) | POLBSLC2A1SLC2A3ALDH1A1CYP3A4 | |
| SCHEMBL11944476 | 0.86 | SLC2A1 (0.33) | POLBSMN1; SMN2LMNAKMT2ASLC2A1 | |
| SCHEMBL11944477 | 0.86 | POLB (0.37) | POLBSMN1; SMN2LMNAKMT2ASLC2A1 | |
| SCHEMBL11945849 | 0.86 | POLB (0.37) | POLBSMN1; SMN2LMNAKMT2ASLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |