Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11945315 | 0.92 | MAPT (0.46) | MAPTALDH1A1DCTPP1SMN1; SMN2POLB | |
| SCHEMBL11945336 | 0.91 | MAPT (0.41) | MAPTALDH1A1DCTPP1SMN1; SMN2POLB | |
| SCHEMBL11945746 | 0.89 | MAPT (0.45) | MAPTALDH1A1DCTPP1SMN1; SMN2POLB | |
| SCHEMBL11945772 | 0.87 | MAPT (0.42) | MAPTALDH1A1DCTPP1SMN1; SMN2POLB | |
| SCHEMBL17058593 | 0.85 | MAPT (0.45) | MAPTALDH1A1DCTPP1SMN1; SMN2POLB | |
| SCHEMBL17058370 | 0.85 | MAPT (0.52) | MAPTALDH1A1DCTPP1SMN1; SMN2POLB | |
| SCHEMBL17058114 | 0.85 | ALDH1A1 (0.61) | MAPTALDH1A1DCTPP1SMN1; SMN2POLB | |
| SCHEMBL11945497 | 0.84 | POLB (0.45) | MAPTALDH1A1DCTPP1SMN1; SMN2POLB | |
| SCHEMBL17058147 | 0.84 | SMN1; SMN2 (0.39) | MAPTALDH1A1DCTPP1SMN1; SMN2POLB | |
| SCHEMBL11944574 | 0.84 | MAPT (0.38) | MAPTALDH1A1DCTPP1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |