Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.37 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11944539 | 0.87 | ALDH1A1 (0.48) | SLC2A1SLC2A3MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11944497 | 0.85 | ALDH1A1 (0.38) | SLC2A1SLC2A3MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL17057924 | 0.84 | SLC2A1 (0.35) | SLC2A1SLC2A3MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL14080951 | 0.81 | ALDH1A1 (0.37) | SLC2A1SLC2A3MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11944423 | 0.79 | POLB (0.42) | SLC2A1SLC2A3MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11944432 | 0.78 | ALDH1A1 (0.48) | SLC2A1SLC2A3MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL17057805 | 0.77 | CA12 (0.37) | CA12CA1CA2CA9SLC2A1 | |
| SCHEMBL11944358 | 0.76 | ALDH1A1 (0.38) | SLC2A1SLC2A3MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11944389 | 0.76 | ALDH1A1 (0.38) | SLC2A1SLC2A3MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL14899771 | 0.73 | SMN1; SMN2 (0.49) | SLC2A1SLC2A3MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |