Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11946064 | 0.85 | MAPT (0.37) | ALDH1A1MAPTNPSR1CYP3A4CYP2C19 | |
| SCHEMBL17058382 | 0.80 | SLC2A1 (0.35) | LMNAALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL17058276 | 0.80 | SLC2A1 (0.34) | LMNAALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL17058510 | 0.79 | SLC2A1 (0.32) | — | |
| SCHEMBL11946043 | 0.79 | MAPT (0.37) | ALDH1A1MAPTNPSR1CYP3A4CYP2C19 | |
| SCHEMBL11944396 | 0.79 | MAPT (0.38) | ALDH1A1KMT2AMAPTNPSR1MEN1 | |
| SCHEMBL17058015 | 0.78 | SLC2A1 (0.35) | LMNAALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL17058239 | 0.78 | NPBWR1 (0.32) | NPSR1CYP3A4CYP2C19 | |
| SCHEMBL11944666 | 0.78 | MAPT (0.37) | ALDH1A1MAPTNPSR1KDM4ECYP3A4 | |
| SCHEMBL11945379 | 0.78 | NPSR1 (0.39) | LMNAALDH1A1KMT2AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |