Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 10/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.35 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.32 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.32 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11945946 | 0.81 | NPSR1 (0.41) | PDE4BPDE11AALDH1A1MCL1NPSR1 | |
| SCHEMBL17058008 | 0.80 | SMN1; SMN2 (0.38) | DCTPP1ALDH1A1NPSR1KDM4EHPGD | |
| SCHEMBL17058513 | 0.74 | NPBWR1 (0.39) | DCTPP1ALDH1A1MCL1NPSR1TSHR | |
| SCHEMBL17058205 | 0.74 | SLC2A1 (0.34) | DCTPP1ALDH1A1NPSR1SLC2A1SLC2A3 | |
| SCHEMBL17058209 | 0.74 | SLC2A1 (0.33) | SLC2A1SLC2A3 | |
| SCHEMBL17058448 | 0.72 | NPBWR1 (0.36) | DCTPP1ALDH1A1MCL1NPSR1KDM4E | |
| SCHEMBL17058485 | 0.71 | NPSR1 (0.39) | DCTPP1ALDH1A1MCL1NPSR1KDM4E | |
| SCHEMBL17058432 | 0.71 | MCHR1 (0.38) | ALDH1A1NPSR1SLC2A1SLC2A3 | |
| SCHEMBL17058230 | 0.71 | SMN1; SMN2 (0.58) | DCTPP1ALDH1A1NPSR1GAA | |
| SCHEMBL17058467 | 0.70 | NPSR1 (0.33) | ALDH1A1NPSR1KDM4ESLC2A1SLC2A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |