Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 2/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.40 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20732994 | 0.81 | CCR1 (0.50) | PARP1CCNCCDK8GAKRIPK2 | |
| SCHEMBL17059461 | 0.76 | PARP1 (0.47) | PARP1CCNCCDK8GAKRIPK2 | |
| SCHEMBL304325 | 0.75 | MAPT (0.56) | KDM4EMAPK1NPSR1MAPTALDH1A1 | |
| SCHEMBL1147789 | 0.74 | KDM4E (0.64) | GAKRIPK2COQ8ANLKKDM4E | |
| SCHEMBL4478426 | 0.74 | CDK8 (0.46) | CCNCCDK8GAKRIPK2COQ8A | |
| SCHEMBL31355748 | 0.73 | SMN1; SMN2 (0.51) | PARP1CCNCCDK8GAKRIPK2 | |
| SCHEMBL20733040 | 0.73 | PARP1 (0.44) | PARP1CCNCCDK8GAKRIPK2 | |
| SCHEMBL29915158 | 0.73 | DYRK1B (0.47) | PARP1CCNCCDK8GAKRIPK2 | |
| SCHEMBL18970831 | 0.73 | PARP1 (0.44) | PARP1CCNCCDK8GAKRIPK2 | |
| SCHEMBL599869 | 0.73 | DYRK1B (0.47) | PARP1CCNCCDK8GAKRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-B1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-02 | — | — | EP | disclosed |