Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 7/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | GAK | O14976 | 2/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.56 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | FADS1 | O60427 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 5/20 | 0.34 |
| ▸ | BRAF | P15056 | 5/20 | 0.34 |
| ▸ | ULK1 | O75385 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17059481 | 0.84 | RIPK2 (0.58) | RIPK2KCNH2GAKTGFBR1LCK | |
| SCHEMBL14730928 | 0.79 | RIPK2 (0.70) | RIPK2KCNH2GAKTGFBR1LCK | |
| SCHEMBL17059503 | 0.77 | RIPK2 (0.57) | RIPK2KCNH2GAKTGFBR1LCK | |
| SCHEMBL14717834 | 0.76 | RIPK2 (0.69) | RIPK2KCNH2GAKTGFBR1LCK | |
| SCHEMBL2595620 | 0.76 | RIPK2 (1.00) | RIPK2KCNH2GAKTGFBR1LCK | |
| SCHEMBL14730868 | 0.73 | RIPK2 (0.72) | RIPK2KCNH2GAKTGFBR1LCK | |
| SCHEMBL2592512 | 0.72 | RIPK2 (0.84) | RIPK2KCNH2GAKTGFBR1LCK | |
| SCHEMBL2595766 | 0.72 | RIPK2 (1.00) | RIPK2KCNH2GAKTGFBR1LCK | |
| SCHEMBL2595069 | 0.72 | RIPK2 (1.00) | RIPK2KCNH2GAKTGFBR1LCK | |
| SCHEMBL31248455 | 0.72 | RIPK2 (1.00) | RIPK2KCNH2GAKTGFBR1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-B1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-02 | — | — | EP | disclosed |