Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.85 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | JAK1 | P23458 | 1/20 | 0.62 |
| ▸ | TYK2 | P29597 | 1/20 | 0.62 |
| ▸ | JAK3 | P52333 | 1/20 | 0.62 |
| ▸ | BLK | P51451 | 3/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
| ▸ | ITK | Q08881 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17059694 | 0.92 | EGFR (1.00) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL17059685 | 0.91 | EGFR (1.00) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL17059610 | 0.86 | EGFR (0.64) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL17059659 | 0.86 | EGFR (0.87) | EGFRJAK3 | |
| SCHEMBL17059692 | 0.84 | EGFR (0.77) | EGFRITKBTK | |
| SCHEMBL17059708 | 0.84 | EGFR (0.77) | EGFRBLKFLT3ITK | |
| SCHEMBL17059589 | 0.84 | EGFR (0.80) | EGFRITKBTK | |
| SCHEMBL10127802 | 0.84 | EGFR (0.87) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL17059592 | 0.84 | EGFR (0.84) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL17059603 | 0.83 | EGFR (0.60) | EGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015127873-A1 | ARYLAMINO PYRAMIDINE COMPOUND AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | 上海海雁医药科技有限公司 | 2015-09-03 | — | — | WO | disclosed |