Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.77 |
| ▸ | ITK | Q08881 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | BLK | P51451 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17059589 | 0.90 | EGFR (0.80) | EGFRITK | |
| SCHEMBL17059692 | 0.90 | EGFR (0.77) | EGFRITK | |
| SCHEMBL17059660 | 0.89 | EGFR (0.68) | EGFRITK | |
| SCHEMBL17059596 | 0.87 | EGFR (1.00) | EGFRITK | |
| SCHEMBL17059638 | 0.85 | EGFR (0.82) | EGFRITK | |
| SCHEMBL17059604 | 0.84 | EGFR (0.85) | EGFRITKFLT3BLK | |
| SCHEMBL17059588 | 0.83 | EGFR (0.61) | EGFRITKKDRTEK | |
| SCHEMBL17059694 | 0.83 | EGFR (1.00) | EGFRFLT3BLK | |
| SCHEMBL17059677 | 0.83 | EGFR (1.00) | EGFRITK | |
| SCHEMBL14791186 | 0.82 | ITK (0.81) | EGFRITKBLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015127873-A1 | ARYLAMINO PYRAMIDINE COMPOUND AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | 上海海雁医药科技有限公司 | 2015-09-03 | — | — | WO | disclosed |