SCHEMBL17059668 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	EGFR	P00533	16/20	0.83

▸	CCNT1	O60563	1/20	0.59

▸	CCNK	O75909	1/20	0.59

▸	CYP3A4	P08684	1/20	0.59

▸	CCND3	P30281	1/20	0.59

▸	CDK9	P50750	1/20	0.59

▸	CDK6	Q00534	1/20	0.59

▸	JAK3	P52333	2/20	0.57

▸	BTK	Q06187	2/20	0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL17059685	0.91	EGFR (1.00)	EGFRJAK3BTK
SCHEMBL17059592	0.90	EGFR (0.84)	EGFRJAK3BTK
SCHEMBL17059644	0.85	EGFR (1.00)	EGFRJAK3BTK
SCHEMBL10127802	0.84	EGFR (0.87)	EGFRJAK3BTK
SCHEMBL17059604	0.82	EGFR (0.85)	EGFRJAK3BTK
SCHEMBL17059694	0.81	EGFR (1.00)	EGFRJAK3BTK
SCHEMBL17059632	0.81	EGFR (0.75)	EGFR
SCHEMBL29847775	0.80	FGFR1 (0.77)	EGFRCCNT1CCNKCYP3A4CCND3
SCHEMBL16515007	0.80	FGFR1 (0.77)	EGFRCCNT1CCNKCYP3A4CCND3
SCHEMBL17059606	0.79	EGFR (1.00)	EGFRJAK3BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2015127873-A1	ARYLAMINO PYRAMIDINE COMPOUND AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM	上海海雁医药科技有限公司	2015-09-03	—	—	WO	disclosed