Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 5/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | HTR6 | P50406 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311305 | 0.90 | SIRT6 (0.62) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL310322 | 0.89 | SIRT6 (0.58) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL310870 | 0.89 | SIRT6 (0.61) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL310468 | 0.89 | SIRT6 (0.74) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL3316399 | 0.88 | SIRT6 (0.73) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL30340499 | 0.88 | SIRT6 (0.73) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL310489 | 0.88 | SIRT6 (0.73) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL2226779 | 0.86 | SIRT6 (0.74) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL30679040 | 0.86 | SIRT6 (0.74) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL310234 | 0.85 | SIRT6 (0.68) | SIRT6ALDH1A1LMNAMAPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015127873-A1 | ARYLAMINO PYRAMIDINE COMPOUND AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | 上海海雁医药科技有限公司 | 2015-09-03 | — | — | WO | disclosed |