Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 12/20 | 0.76 |
| ▸ | MAPK7 | Q13164 | 12/20 | 0.76 |
| ▸ | DCLK1 | O15075 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18379253 | 1.00 | BRD4 (0.76) | BRD4MAPK7DCLK1KCNH2BRD2 | |
| SCHEMBL17059839 | 0.91 | BRD4 (0.78) | BRD4MAPK7DCLK1KCNH2BRD2 | |
| SCHEMBL17059834 | 0.90 | MAPK7 (0.73) | BRD4MAPK7DCLK1KCNH2BRD2 | |
| SCHEMBL17059926 | 0.87 | MAPK7 (0.82) | BRD4MAPK7DCLK1KCNH2BRD2 | |
| SCHEMBL18369858 | 0.86 | MAPK7 (1.00) | BRD4MAPK7DCLK1KCNH2BRD2 | |
| SCHEMBL17059803 | 0.86 | MAPK7 (1.00) | BRD4MAPK7DCLK1KCNH2BRD2 | |
| SCHEMBL18369908 | 0.86 | MAPK7 (0.80) | BRD4MAPK7DCLK1KCNH2BRD2 | |
| SCHEMBL17059837 | 0.86 | MAPK7 (1.00) | BRD4MAPK7DCLK1KCNH2BRD2 | |
| SCHEMBL18379147 | 0.85 | MAPK7 (0.79) | BRD4MAPK7DCLK1KCNH2BRD2 | |
| SCHEMBL18379209 | 0.85 | MAPK7 (0.79) | BRD4MAPK7DCLK1KCNH2BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170008888-A1 | HETEROCYCLIC COMPOUNDS | ACTIVX BIOSCIENCES, INC. | 2017-01-12 | — | — | US | disclosed |
| US-20170008888-A1 | HETEROCYCLIC COMPOUNDS | ACTIVX BIOSCIENCES, INC. | 2017-01-12 | — | — | US | disclosed |
| WO-2015129927-A1 | HETEROCYCLIC COMPOUNDS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2015-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008888-A1 | HETEROCYCLIC COMPOUNDS | BET1, EP300, RBBP5 | BRD4 4/4885MAPK7 58/4885DCLK1 3272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.