SCHEMBL17060567

COC(=O)c1cccc(-c2cnc(C(=O)C3Cc4ccc(OCc5ccccc5)cc4C3)o2)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	FAAH	O00519	19/20	1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL17067872	0.94	FAAH (1.00)	FAAH
SCHEMBL17067874	0.92	FAAH (1.00)	FAAH
SCHEMBL17060550	0.89	FAAH (1.00)	FAAH
SCHEMBL18264452	0.88	FAAH (0.81)	FAAH
SCHEMBL17060553	0.85	FAAH (1.00)	FAAH
SCHEMBL17067930	0.85	FAAH (1.00)	FAAH
SCHEMBL12471934	0.84	FAAH (1.00)	FAAH
SCHEMBL17060549	0.84	FAAH (0.72)	FAAH
SCHEMBL12471955	0.83	FAAH (1.00)	FAAH
SCHEMBL18264450	0.82	FAAH (0.82)	FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-9504675-B2	Alpha-ketoheterocycles and methods of making and using	THE SCRIPPS RESEARCH INSTITUTE (US)	2016-11-29	—	—	US	disclosed
US-9504675-B2	Alpha-ketoheterocycles and methods of making and using	THE SCRIPPS RESEARCH INSTITUTE (US)	2016-11-29	—	—	US	disclosed
EP-2670245-B1	ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING	SCRIPPS RESEARCH INST (US)	2015-09-09	—	—	EP	disclosed
EP-2670245-B1	ALPHA-KETOHETEROCYCLES AND METHODS OF MAKING AND USING	SCRIPPS RESEARCH INST (US)	2015-09-09	—	—	EP	disclosed