Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 13/20 | 0.43 |
| ▸ | CHUK | O15111 | 10/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705176 | 1.00 | IKBKB (0.43) | IKBKBCHUKSLC6A4SLC6A3ROCK1 | |
| SCHEMBL1705985 | 0.91 | IKBKB (0.45) | IKBKBCHUKSLC6A4ROCK1LCK | |
| SCHEMBL1705537 | 0.91 | IKBKB (0.45) | IKBKBCHUKSLC6A4ROCK1LCK | |
| SCHEMBL1706128 | 0.86 | IKBKB (0.48) | IKBKBCHUKROCK1LCKAKT1 | |
| SCHEMBL1705326 | 0.86 | IKBKB (0.48) | IKBKBCHUKROCK1LCKAKT1 | |
| SCHEMBL1705787 | 0.86 | IKBKB (0.48) | IKBKBCHUKROCK1LCKAKT1 | |
| SCHEMBL1706028 | 0.83 | IKBKB (0.41) | IKBKBCHUKROCK1LCKAKT1 | |
| SCHEMBL1705242 | 0.83 | IKBKB (0.41) | IKBKBCHUKROCK1LCKAKT1 | |
| SCHEMBL1705543 | 0.82 | IKBKB (0.45) | IKBKBCHUKROCK1LCKAKT1 | |
| SCHEMBL1706026 | 0.82 | IKBKB (0.45) | IKBKBCHUKROCK1LCKAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8710228-B2 | Cycloalkylamine substituted isoquinoline derivatives | SANOFI (FR) | 2014-04-29 | — | — | US | disclosed |
| EP-2125746-B1 | CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE DERIVATIVES | SANOFI SA (FR) | 2012-04-18 | — | — | EP | disclosed |
| US-20100081671-A1 | Cycloalkylamine substituted isoquinoline derivatives | SANOFI-AVENTIS (FR) | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081671-A1 | Cycloalkylamine substituted isoquinoline derivatives | MYLK2, MYLK, MYLK3 | IKBKB 1991/4885CHUK 1876/4885SLC6A4 2545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.