Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | ASPH | Q12797 | 2/20 | 0.38 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.36 |
| ▸ | KDM5C | P41229 | 2/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29696567 | 0.84 | GDA (0.39) | HSD17B10CYP2C19TDP1KDM4AKDM5C | |
| SCHEMBL30880788 | 0.75 | KDM4C (0.50) | KDM4EASPHKDM8TDP1ALDH1A1 | |
| SCHEMBL28462590 | 0.75 | KDM4C (0.50) | KDM4EASPHKDM8TDP1ALDH1A1 | |
| SCHEMBL6022428 | 0.73 | HCAR2 (0.37) | KDM4EASPHKDM8TDP1KDM4A | |
| SCHEMBL1056425 | 0.72 | KDM4A (0.37) | KDM4AKDM5CKDM5BKDM4BPOLB | |
| SCHEMBL31394920 | 0.72 | KDM4E (0.43) | HSD17B10CYP2C19KDM4EASPHKDM8 | |
| SCHEMBL12756128 | 0.71 | HSD17B10 (0.48) | HSD17B10CYP2C19KDM4ETDP1ALDH1A1 | |
| SCHEMBL21437991 | 0.70 | HSD17B10 (0.44) | HSD17B10CYP2C19KDM4ETDP1ALDH1A1 | |
| SCHEMBL4791037 | 0.70 | EGLN1 (0.63) | HSD17B10CYP2C19KDM4EASPHKDM8 | |
| SCHEMBL31485777 | 0.68 | KDM4A (0.37) | CYP2C19KDM4AKDM5CKDM5BKDM4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440558-A1 | DIHYDROPYRROLONAPHTYRIDINONE COMPOUNDS AS INHIBITORS OF JAK | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010144486-A1 | DIHYDROPYRROLONAPHTYRIDINONE COMPOUNDS AS INHIBITORS OF JAK | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |