Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL121598 | 0.85 | HRH3 (0.67) | HRH3KMT2A | |
| Hydrochloric Acid SCHEMBL1706094 | 0.84 | HRH3 (0.66) | HRH3KMT2A | |
| SCHEMBL196937 | 0.81 | HRH3 (0.62) | HRH3KMT2ACHRNA7 | |
| Hydrochloric Acid SCHEMBL1169646 | 0.80 | HRH3 (0.61) | HRH3KMT2ACHRNA7 | |
| SCHEMBL4505554 | 0.75 | HRH3 (0.89) | HRH3 | |
| SCHEMBL14006753 | 0.74 | HRH3 (0.78) | HRH3 | |
| SCHEMBL1432434 | 0.74 | HRH3 (0.56) | HRH3KMT2ACHRNA7 | |
| SCHEMBL1432431 | 0.74 | HRH3 (0.56) | HRH3KMT2ACHRNA7 | |
| SCHEMBL13503751 | 0.73 | DRD3 (0.71) | HRH3CHRNA7EPHX2 | |
| SCHEMBL4491534 | 0.72 | HRH3 (0.84) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195307-B1 | PIPERAZINE DERIVATIVE HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LTD (GB) | 2012-04-18 | — | — | EP | claimed |