Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GCK | P35557 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1169646 | 0.99 | HRH3 (0.61) | HRH3KMT2ACHRNA7MEN1GCK | |
| SCHEMBL121598 | 0.95 | HRH3 (0.67) | HRH3KMT2A | |
| Hydrochloric Acid SCHEMBL1706094 | 0.94 | HRH3 (0.66) | HRH3KMT2A | |
| SCHEMBL12385099 | 0.89 | KMT2A (0.59) | HRH3KMT2ACHRNA7MEN1GCK | |
| SCHEMBL524345 | 0.85 | HRH3 (0.59) | HRH3CHRNA7 | |
| SCHEMBL1706335 | 0.81 | HRH3 (0.56) | HRH3KMT2ACHRNA7 | |
| SCHEMBL3711691 | 0.80 | HRH3 (0.61) | HRH3 | |
| SCHEMBL4619912 | 0.80 | HRH3 (0.66) | HRH3KMT2AMEN1 | |
| SCHEMBL523985 | 0.79 | HRH3 (0.57) | HRH3CHRNA7 | |
| Hydrochloric Acid SCHEMBL4134453 | 0.79 | HRH3 (0.56) | HRH3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492375-B2 | 1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists | GLAXO GROUP LIMITED (GB) | 2013-07-23 | — | — | US | claimed |
| JP-2012500823-A | — | — | 2012-01-12 | — | — | JP | claimed |
| JP-2012500192-A | — | — | 2012-01-05 | — | — | JP | claimed |
| US-20110189280-A1 | DOSAGE FORM COMPRISING 1-ISOPROPYL-4-HEXAHYDRO-1H-1,4-DIAZEPINE OR A SALT THEREOF | GLAXO GROUP LIMITED (GB) | 2011-08-04 | — | — | US | claimed |
| US-20110190274-A1 | SALT OF, AND PROCESSES FOR THE PREPARATION OF, 1-ISOPROPYL-4-HEXAHYDRO-1H-1,4-DIAZEPINE | GLAXO GROUP LIMITED | 2011-08-04 | — | — | US | claimed |
| EP-2328587-A1 | DOSAGE FORM COMPRISING 1-ISOPROPYL-4-{ [4-(TETRAHYDRO-2H-PYRAN- 4-YLOXY)PHENYL]CARBONYL}HEXAHYDRO-1H-1,4-DIAZEPINE OR A SALT THEREOF | Glaxo Group Limited (GB) | 2011-06-08 | — | — | EP | claimed |
| EP-2326642-A2 | SALT OF, AND PROCESSES FOR THE PREPARATION OF, 1-ISOPROPYL-4-{[4-(TETRAHYDRO-2H-PYRAN- 4-YLOXY)PHENYL]CARBONYL}HEXAHYDRO-1H-1,4-DIAZEPINE | Glaxo Group Limited (GB) | 2011-06-01 | — | — | EP | claimed |
| US-20110039833-A1 | 1-BENZOYL SUBSTITUTED DIAZEPINE DERIVATIVES AS SELECTIVE HISTAMINE H3 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2011-02-17 | — | — | US | claimed |
| US-7846922-B2 | 1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists | GLAXO GROUP LIMITED (GB) | 2010-12-07 | — | — | US | claimed |
| WO-2010023170-A1 | Dosage form comprising 1-isopropyl-4-{[4-(tetrahydro-2H-pyran- 4-yloxy)phenyl]carbonyl}hexahydro-1H-1,4-diazepine or a salt thereof | GLAXO GROUP LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |
| WO-2010018231-A2 | SALT OF, AND PROCESSES FOR THE PREPARATION OF, 1-ISOPROPYL-4-{[4-(TETRAHYDRO-2H-PYRAN- 4-YLOXY)PHENYL]CARBONYL}HEXAHYDRO-1H-1,4-DIAZEPINE | GLAXO GROUP LIMITED (GB) | 2010-02-18 | — | — | WO | claimed |
| US-20080045505-A1 | 1-Benzoyl Substituted Diazepine Derivatives As Selective Histamine H3 Receptor Agonists | GLAXO GROUP LIMITED (GB) | 2008-02-21 | — | — | US | claimed |
| US-8492375-B2 | 1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists | GLAXO GROUP LIMITED (GB) | 2013-07-23 | — | — | US | disclosed |
| US-8492375-B2 | 1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists | GLAXO GROUP LIMITED (GB) | 2013-07-23 | — | — | US | disclosed |
| US-8288389-B2 | Piperazine derivative having affinity for the histamine H3 receptor | GLAXO GROUP LIMITED (GB) | 2012-10-16 | — | — | US | disclosed |
| US-8288389-B2 | Piperazine derivative having affinity for the histamine H3 receptor | GLAXO GROUP LIMITED (GB) | 2012-10-16 | — | — | US | disclosed |
| US-20090170869-A1 | PIPERAZINE DERIVATIVE HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | US | disclosed |
| WO-2009030716-A1 | PIPERAZINE DERIVATIVE HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2009-03-12 | — | — | WO | disclosed |
| US-20080045505-A1 | 1-Benzoyl Substituted Diazepine Derivatives As Selective Histamine H3 Receptor Agonists | GLAXO GROUP LIMITED (GB) | 2008-02-21 | — | — | US | disclosed |
| US-20080045505-A1 | 1-Benzoyl Substituted Diazepine Derivatives As Selective Histamine H3 Receptor Agonists | GLAXO GROUP LIMITED (GB) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039833-A1 | 1-BENZOYL SUBSTITUTED DIAZEPINE DERIVATIVES AS SELECTIVE HISTAMINE H3 RECEPTOR AGONISTS | HRH3, HRH4, HRH1 | HRH3 1/4885KMT2A 356/4885CHRNA7 34/4885 |
| US-20090170869-A1 | PIPERAZINE DERIVATIVE HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | HRH3, HRH4, HRH1 | HRH3 1/4885KMT2A 74/4885CHRNA7 50/4885 |
| US-20110190274-A1 | SALT OF, AND PROCESSES FOR THE PREPARATION OF, 1-ISOPROPYL-4-HEXAHYDRO-1H-1,4-DIAZEPINE | GRIK4, GRIK1, IPO4 | HRH3 72/4885KMT2A 1083/4885CHRNA7 141/4885 |
| US-20110189280-A1 | DOSAGE FORM COMPRISING 1-ISOPROPYL-4-HEXAHYDRO-1H-1,4-DIAZEPINE OR A SALT THEREOF | HPD, ME1, SLC16A1 | HRH3 133/4885KMT2A 1566/4885CHRNA7 259/4885 |
| US-20080045505-A1 | 1-Benzoyl Substituted Diazepine Derivatives As Selective Histamine H3 Receptor Agonists | HRH3, HRH4, HRH1 | HRH3 1/4885KMT2A 416/4885CHRNA7 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.