SCHEMBL17064385

SCHEMBL17064385

Nc1cc(C(O)c2nccs2)ccc1F

nearest known ligand 0.44

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PRKDC P78527 8/20 0.44
KCNH2 Q12809 5/20 0.44
ALOX5 P09917 1/20 0.42
ADAM17 P78536 1/20 0.37
CTSA P10619 6/20 0.35
CNR1 P21554 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20431813 0.82 PRKDC (0.44) PRKDCKCNH2ALOX5CTSA
SCHEMBL17602511 0.82 PRKDC (0.44) PRKDCKCNH2ALOX5ADAM17CTSA
SCHEMBL17073466 0.82 CTSA (0.33) PRKDCKCNH2CTSACNR1
SCHEMBL3993652 0.79 ALOX5 (0.42) PRKDCKCNH2ALOX5ADAM17CTSA
SCHEMBL7803717 0.78 PRKDC (0.46) PRKDCKCNH2ALOX5CTSA
SCHEMBL31090349 0.78 ALOX5 (0.41) PRKDCKCNH2ALOX5ADAM17CTSA
SCHEMBL12064962 0.78 CTSA (0.45) PRKDCKCNH2ALOX5CTSA
SCHEMBL17064896 0.77 ALOX5 (0.53) PRKDCKCNH2ALOX5CTSA
SCHEMBL17064827 0.77 PRKDC (0.43) PRKDCKCNH2ALOX5
SCHEMBL31067641 0.77 PRKDC (0.43) PRKDCKCNH2ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4663636-A2 TRIFLUOROMETHYL SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS BioCryst Pharmaceuticals, Inc. (US) 2025-12-17 EP disclosed
US-20250270171-A1 HUMAN PLASMA KALLIKREIN INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-08-28 US disclosed
US-20250257040-A1 HUMAN PLASMA KALLIKREIN INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-08-14 US disclosed
EP-4180424-B1 SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS BIOCRYST PHARM INC (US) 2025-06-25 EP disclosed
US-12162838-B2 Human plasma kallikrein inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2024-12-10 US disclosed
US-12116346-B2 Human plasma kallikrein inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2024-10-15 US disclosed
CN-113307772-B Human plasma kallikrein inhibitors 拜奥克里斯特制药公司 2024-06-28 CN disclosed
US-20240150296-A1 HUMAN PLASMA KALLIKREIN INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-05-09 US disclosed
US-20240150295-A1 HUMAN PLASMA KALLIKREIN INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-05-09 US disclosed
US-11708333-B2 Human plasma kallikrein inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2023-07-25 US disclosed
US-10329260-B2 Human plasma kallikrein inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2019-06-25 US disclosed
US-10329260-B2 Human plasma kallikrein inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2019-06-25 US disclosed
US-20180354906-A1 HUMAN PLASMA KALLIKREIN INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2018-12-13 US disclosed
US-10125102-B2 Human plasma kallikrein inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2018-11-13 US disclosed
US-20180258049-A1 HUMAN PLASMA KALLIKREIN INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2018-09-13 US disclosed
US-20170073314-A1 HUMAN PLASMA KALLIKREIN INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2017-03-16 US disclosed
US-20170073314-A1 HUMAN PLASMA KALLIKREIN INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2017-03-16 US disclosed
US-20170073314-A1 HUMAN PLASMA KALLIKREIN INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2017-03-16 US disclosed
EP-3113772-A1 HUMAN PLASMA KALLIKREIN INHIBITORS Biocryst Pharmaceuticals, Inc. (US) 2017-01-11 EP disclosed
WO-2015134998-A1 HUMAN PLASMA KALLIKREIN INHIBITORS BIOCRYST PHARMACEUTICALS, INC. (US) 2015-09-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180354906-A1 HUMAN PLASMA KALLIKREIN INHIBITORS KLKB1, KLK1, KLK5 PRKDC 678/4885KCNH2 752/4885ALOX5 1170/4885
US-12116346-B2 Human plasma kallikrein inhibitors KLKB1, KLK5, KLK1 PRKDC 657/4885KCNH2 623/4885ALOX5 899/4885
US-20250270171-A1 HUMAN PLASMA KALLIKREIN INHIBITORS KLKB1, KLK5, KLK1 PRKDC 657/4885KCNH2 623/4885ALOX5 899/4885
US-20240150296-A1 HUMAN PLASMA KALLIKREIN INHIBITORS KLKB1, KLK5, KLK1 PRKDC 657/4885KCNH2 623/4885ALOX5 899/4885
US-10329260-B2 Human plasma kallikrein inhibitors KLKB1, KLK1, KLK5 PRKDC 678/4885KCNH2 752/4885ALOX5 1170/4885
US-10125102-B2 Human plasma kallikrein inhibitors KLKB1, KLK1, KLK5 PRKDC 678/4885KCNH2 752/4885ALOX5 1170/4885
US-20170073314-A1 HUMAN PLASMA KALLIKREIN INHIBITORS KLKB1, KLK1, KLK5 PRKDC 678/4885KCNH2 752/4885ALOX5 1170/4885
US-20240150295-A1 HUMAN PLASMA KALLIKREIN INHIBITORS KLKB1, KLK5, KLK1 PRKDC 657/4885KCNH2 623/4885ALOX5 899/4885
US-20250257040-A1 HUMAN PLASMA KALLIKREIN INHIBITORS KLKB1, KLK5, KLK1 PRKDC 657/4885KCNH2 623/4885ALOX5 899/4885
US-11708333-B2 Human plasma kallikrein inhibitors KLKB1, KLK1, KLK5 PRKDC 763/4885KCNH2 996/4885ALOX5 1315/4885
US-20180258049-A1 HUMAN PLASMA KALLIKREIN INHIBITORS KLKB1, KLK1, KLK5 PRKDC 678/4885KCNH2 752/4885ALOX5 1170/4885
US-12162838-B2 Human plasma kallikrein inhibitors KLKB1, KLK5, KLK1 PRKDC 657/4885KCNH2 623/4885ALOX5 899/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.