Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.36 |
| ▸ | KDM5C | P41229 | 2/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.36 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | TET3 | O43151 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362870 | 0.83 | UHRF1 (0.43) | UHRF1PROKR1SMARCA2SMARCA4HDAC3 | |
| SCHEMBL12672263 | 0.81 | UHRF1 (0.42) | UHRF1PROKR1SMARCA2SMARCA4HDAC3 | |
| SCHEMBL1884527 | 0.81 | GSK3B (0.50) | UHRF1GSK3BPROKR1SMARCA2SMARCA4 | |
| SCHEMBL29740179 | 0.81 | GSK3B (0.50) | UHRF1GSK3BPROKR1SMARCA2SMARCA4 | |
| SCHEMBL29740180 | 0.81 | GSK3B (0.50) | UHRF1GSK3BPROKR1SMARCA2SMARCA4 | |
| Hydrochloric Acid SCHEMBL1924951 | 0.80 | UHRF1 (0.41) | UHRF1PROKR1SMARCA2SMARCA4HDAC3 | |
| Hydrochloric Acid SCHEMBL14676437 | 0.80 | GSK3B (0.48) | UHRF1GSK3BPROKR1SMARCA2SMARCA4 | |
| Bromide SCHEMBL14676183 | 0.80 | GSK3B (0.48) | UHRF1GSK3BPROKR1SMARCA2SMARCA4 | |
| Bromide SCHEMBL23407677 | 0.79 | GSK3B (0.47) | UHRF1GSK3BPROKR1SMARCA2SMARCA4 | |
| SCHEMBL3356107 | 0.78 | UHRF1 (0.50) | UHRF1PROKR1SMARCA2SMARCA4HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3113772-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2017-01-11 | — | — | EP | disclosed |
| WO-2015134998-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2015-09-11 | — | — | WO | disclosed |