Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19799224 | 0.79 | CYP11B1 (0.39) | CYP11B1TRPV6NPC1NFKB1MAPK1 | |
| SCHEMBL31508335 | 0.78 | CYP11B1 (0.41) | CYP11B1TRPV6PARP1KCNH2CACNA1I | |
| SCHEMBL10484015 | 0.76 | CYP11B1 (0.42) | CYP11B1TRPV6NPC1NFKB1MAPK1 | |
| SCHEMBL4590967 | 0.76 | CYP11B1 (0.42) | CYP11B1TRPV6NPC1NFKB1MAPK1 | |
| SCHEMBL9085129 | 0.75 | RAB9A (0.43) | LNPEPNPC1NFKB1MAPK1RAB9A | |
| SCHEMBL10483902 | 0.74 | CYP11B1 (0.41) | CYP11B1TRPV6NPC1NFKB1MAPK1 | |
| SCHEMBL17242029 | 0.74 | CYP11B1 (0.41) | CYP11B1TRPV6NPC1NFKB1MAPK1 | |
| SCHEMBL13430063 | 0.74 | CYP11B1 (0.41) | CYP11B1TRPV6NPC1NFKB1MAPK1 | |
| SCHEMBL20576042 | 0.74 | CYP11B1 (0.41) | CYP11B1NPC1NFKB1MAPK1RAB9A | |
| SCHEMBL1134968 | 0.74 | CYP11B1 (0.41) | CYP11B1NPC1NFKB1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3113772-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2017-01-11 | — | — | EP | disclosed |
| WO-2015134998-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2015-09-11 | — | — | WO | disclosed |