Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 17/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17064825 | 0.92 | KLKB1 (0.37) | KLKB1VCPPARP1USP30 | |
| SCHEMBL17064774 | 0.81 | KCNH2 (0.33) | PARP1 | |
| SCHEMBL17064969 | 0.76 | KLKB1 (0.39) | KLKB1 | |
| SCHEMBL18604783 | 0.75 | KLKB1 (0.57) | KLKB1 | |
| SCHEMBL17064820 | 0.75 | KLKB1 (0.38) | KLKB1USP30 | |
| SCHEMBL17064477 | 0.75 | KLKB1 (0.40) | KLKB1USP30 | |
| SCHEMBL17073498 | 0.74 | KLKB1 (0.38) | KLKB1USP30 | |
| SCHEMBL18604738 | 0.74 | KLKB1 (0.71) | KLKB1 | |
| SCHEMBL17064963 | 0.73 | KLKB1 (0.42) | KLKB1 | |
| SCHEMBL17064739 | 0.71 | KLKB1 (0.60) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3113772-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2017-01-11 | — | — | EP | disclosed |
| WO-2015134998-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2015-09-11 | — | — | WO | disclosed |