Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15261253 | 0.90 | PIK3CA (0.31) | PIK3CA | |
| SCHEMBL871896 | 0.84 | TSHR (0.37) | PIK3CAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL872848 | 0.82 | ADORA2A (0.36) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL872376 | 0.80 | ALDH1A1 (0.36) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL872488 | 0.77 | PDE5A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL876961 | 0.75 | EEF2K (0.34) | PIK3CAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15261850 | 0.74 | PIK3CA (0.33) | PIK3CAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17066867 | 0.70 | ADORA2A (0.35) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL872374 | 0.67 | ADORA2A (0.40) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL874074 | 0.66 | TSHR (0.39) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619211-B1 | FUSED TRICYCLIC COMPOUNDS AS ADENOSINE RECEPTOR ANTAGONIST | ADVINUS THERAPEUTICS LTD (IN) | 2015-09-09 | — | — | EP | disclosed |