Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18854134 | 0.83 | LMNA (0.38) | LMNATDP1TSHRGAANPSR1 | |
| SCHEMBL24909975 | 0.81 | LMNA (0.60) | LMNATDP1TSHRGAANPSR1 | |
| SCHEMBL15730230 | 0.78 | CYP1A2 (0.35) | LMNATDP1TSHRGAANPSR1 | |
| SCHEMBL17066978 | 0.76 | LMNA (0.42) | LMNATDP1TSHRGAANPSR1 | |
| SCHEMBL17066895 | 0.76 | LMNA (0.42) | LMNATDP1TSHRGAANPSR1 | |
| SCHEMBL23501956 | 0.75 | TDP1 (0.39) | LMNATDP1TSHRGAANPSR1 | |
| SCHEMBL15723697 | 0.75 | CYP1A2 (0.33) | LMNACYP1A2CYP2C19TP53 | |
| SCHEMBL20371630 | 0.73 | TDP1 (0.59) | LMNATDP1TSHRGAANPSR1 | |
| SCHEMBL14555306 | 0.73 | LMNA (0.63) | LMNATDP1TSHRGAANPSR1 | |
| SCHEMBL17066937 | 0.72 | LMNA (0.64) | LMNATDP1TSHRGAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729448-B1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES INC (US) | 2015-09-09 | — | — | EP | disclosed |