Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17070587 | 1.00 | TOP1 (0.38) | TOP1EDNRAACHENPC1KMT2A | |
| SCHEMBL16812582 | 1.00 | TOP1 (0.38) | TOP1EDNRAACHENPC1KMT2A | |
| SCHEMBL16745292 | 0.96 | DRD2 (0.32) | TOP1KMT2ADRD2 | |
| SCHEMBL16814045 | 0.96 | DRD2 (0.32) | TOP1KMT2ADRD2 | |
| SCHEMBL16748950 | 0.96 | DRD2 (0.32) | TOP1KMT2ADRD2 | |
| SCHEMBL16745246 | 0.92 | DRD1 (0.33) | — | |
| SCHEMBL16748896 | 0.92 | DRD1 (0.33) | — | |
| SCHEMBL16812580 | 0.92 | DRD1 (0.33) | — | |
| SCHEMBL16813907 | 0.92 | DRD1 (0.33) | — | |
| SCHEMBL16745279 | 0.89 | DRD1 (0.39) | TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527862-B2 | Compounds of chiral aromatic spiroketal diphosphine ligands, preparation methods and uses thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2016-12-27 | — | — | US | disclosed |
| US-20150252055-A1 | COMPOUNDS OF CHIRAL AROMATIC SPIROKETAL DIPHOSPHINE LIGANDS, PREPARATION METHODS AND USES THEREOF | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150252055-A1 | COMPOUNDS OF CHIRAL AROMATIC SPIROKETAL DIPHOSPHINE LIGANDS, PREPARATION METHODS AND USES THEREOF | DDT, DPYD, RECQL | TOP1 1993/4885EDNRA 539/4885ACHE 536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.