Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenhydramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.96 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.96 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.96 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.96 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.96 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.96 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.96 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.96 |
| ▸ | DRD3 | P35462 | 3/20 | 0.96 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.96 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.96 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.96 |
| ▸ | SCN1A | P35498 | 3/20 | 0.96 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.96 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenhydramine SCHEMBL10487818 | 1.00 | LMNA (1.00) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL4064 | 0.98 | SLC6A2 (1.00) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL12543374 | 0.98 | SLC6A2 (1.00) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL11795332 | 0.96 | SLC6A2 (0.96) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL9565209 | 0.96 | SLC6A2 (0.96) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL25219551 | 0.96 | SLC6A2 (0.96) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL28210970 | 0.96 | SLC6A2 (0.96) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL29205078 | 0.96 | SLC6A2 (0.96) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL27912373 | 0.94 | SLC6A2 (0.93) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL28268393 | 0.94 | SLC6A2 (0.93) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 153708 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6360577-B1 | — | — | None | — | — | US | claimed |
| US-12629422-B2 | Agave syrup formulation or suspension for active pharmaceutical agents | GENEXA INC. (US) | 2026-05-19 | — | — | US | claimed |
| US-20260109647-A1 | EPOXY-GEOPOLYMER HYBRID FOAM | CARBOLINE INTERNATIONAL CORPORATION (US) | 2026-04-23 | — | — | US | claimed |
| US-20260109777-A1 | METHODS OF TREATING CANCER USING SUBCUTANEOUS DOSING OF MOSUNETUZUMAB AS A MONOTHERAPY OR IN COMBINATION WITH LENALIDOMIDE | GENENTECH INC (US) | 2026-04-23 | — | — | US | claimed |
| EP-4724114-A1 | CYANOACRYLATE ADHESIVE KITS | Chemence, Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-20260097023-A1 | UNIT ORAL DOSE COMPOSITIONS COMPOSED OF IBUPROFEN OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND FAMOTIDINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR THE TREATMENT OF ACUTE PAIN AND THE REDUCTION OF THE SEVERITY AND/OR RISK OF HEARTBURN AND/OR UPSET STOMACH | SCHABAR RES ASSOCIATES LLC (US) | 2026-04-09 | — | — | US | claimed |
| US-20260090584-A1 | SYSTEMS AND METHODS FOR ESTIMATING AEROSOLIZATION EMISSION | SCIENTIFIC HORIZONS CONSULTING LLC (US) | 2026-04-02 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20260078198-A1 | METHODS FOR TREATING CANCER USING SUBCUTANEOUS DOSING OF MOSUNETUZUMAB IN COMBINATION WITH POLATUZUMAB VEDOTIN | GENENTECH INC (US) | 2026-03-19 | — | — | US | claimed |
| WO-2026041855-A1 | CYANOACRYLATE ADHESIVE KITS | CHEMENCE, INC. (US) | 2026-02-26 | — | — | WO | claimed |
| US-4045347-A | DISINFECTANTS | TII CORPORATION (US) | 1977-08-30 | — | — | US | claimed |
| US-4035296-A | WASTE WATER, GASES | TII CORPORATION (US) | 1977-07-12 | — | — | US | claimed |
| US-4035301-A | GAS FLOW | TII CORPORATION (US) | 1977-07-12 | — | — | US | claimed |
| US-4030509-A | Implantable electrodes for accomplishing ventricular defibrillation and pacing and method of electrode implantation and utilization | Mirowski, Mieczyslaw (US) | 1977-06-21 | — | — | US | claimed |
| US-4016884-A | Atriotomy access device | KWAN GETT CLIFFORD S | 1977-04-12 | — | — | US | claimed |
| US-4014318-A | Circulatory assist device and system | DOCKUM JAMES M | 1977-03-29 | — | — | US | claimed |
| US-3998714-A | TWO STAGE OXIDATION FOR DISINFECTION OF AMMONIA-MATERIALS | TII CORPORATION (US) | 1976-12-21 | — | — | US | claimed |
| US-3993246-A | Nebulizer and method | ERB ELISHA | 1976-11-23 | — | — | US | claimed |
| US-3937248-A | Fluid flow control system employing a plurality of digital valve elements | PROCESS SYSTEMS, INC. (US) | 1976-02-10 | — | — | US | claimed |
| US-3934576-A | Central venous catheter system | AB SUNDSVALLS SPECIALPRODUKTER (SW) | 1976-01-27 | — | — | US | claimed |