Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.59 |
| ▸ | NSD2 | O96028 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.59 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15556210 | 0.83 | MAPT (0.65) | MEN1KMT2AMAPTGAAALDH1A1 | |
| Purpurogallin SCHEMBL1950656 | 0.81 | CDK2 (0.76) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL15555870 | 0.79 | MAPT (0.59) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL12610418 | 0.79 | MAPT (0.51) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL12610186 | 0.78 | CDK2 (0.71) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL12610290 | 0.77 | INPPL1 (0.59) | MEN1KMT2AMAPTGAAALDH1A1 | |
| Purpurogallin SCHEMBL29481120 | 0.76 | CDK2 (1.00) | MEN1KMT2AMAPTGAAALDH1A1 | |
| Purpurogallin SCHEMBL33853 | 0.76 | CDK2 (1.00) | MEN1KMT2AMAPTGAAALDH1A1 | |
| Purpurogallin SCHEMBL2839450 | 0.73 | CDK2 (0.93) | MEN1KMT2AMAPTGAAALDH1A1 | |
| Purpurogallin SCHEMBL15560816 | 0.72 | CDK2 (0.83) | MEN1KMT2AMAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9517993-B2 | Antagonists of the toll-like receptor 1/2 complex | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150251987-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150251987-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | TLR2, TLR1, TLR3 | MEN1 4848/4885KMT2A 2587/4885MAPT 2900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.