Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.80 |
| ▸ | MET | P08581 | 8/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | RIPK3 | Q9Y572 | 4/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2483272 | 0.89 | AURKA (1.00) | AURKAMETAXLRIPK3RIPK1 | |
| SCHEMBL2483645 | 0.76 | AURKA (1.00) | AURKAMETAXLRIPK3RIPK1 | |
| SCHEMBL12786959 | 0.75 | AURKA (0.76) | AURKAMETAXLRIPK3RIPK1 | |
| SCHEMBL16817176 | 0.74 | AXL (0.47) | AURKAMETAXLRIPK3RIPK1 | |
| SCHEMBL3473983 | 0.71 | AURKA (0.76) | AURKAMETAXLMERTK | |
| SCHEMBL2482445 | 0.70 | AURKA (1.00) | AURKA | |
| SCHEMBL15189738 | 0.70 | MST1R (0.56) | METAXLRIPK3RIPK1LCK | |
| SCHEMBL14018080 | 0.69 | MET (0.80) | AURKAMETAXLRIPK3RIPK1 | |
| SCHEMBL12786965 | 0.68 | AURKA (0.62) | AURKAMETAXLRIPK3RIPK1 | |
| SCHEMBL15189718 | 0.67 | MET (0.51) | METAXLRIPK3RIPK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367821-B1 | C-RING MODIFIED TRICYCLIC BENZONAPHTHIRIDINONE PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2015-09-16 | — | — | EP | claimed |