Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.69 |
| ▸ | CNR1 | P21554 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17074601 | 0.84 | CNR2 (0.67) | CNR2CNR1CA12CA1CA2 | |
| SCHEMBL17074603 | 0.82 | CNR2 (1.00) | CNR2CNR1MAPTTP53KDM4E | |
| SCHEMBL17074613 | 0.80 | CA12 (0.62) | CNR2CNR1CA12CA1CA2 | |
| SCHEMBL17074597 | 0.75 | CA12 (0.56) | CNR2CNR1CA12CA1CA2 | |
| SCHEMBL17074606 | 0.75 | CNR2 (0.61) | CNR2CNR1CA12CA1CA2 | |
| SCHEMBL15872032 | 0.72 | KMT2A (0.59) | CNR1MAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL9532108 | 0.71 | ADRA1B (0.55) | CNR2BRD4BRD9 | |
| SCHEMBL9763125 | 0.71 | BRD4 (0.50) | CNR2CNR1NPC1ALDH1A1BRD4 | |
| SCHEMBL2323787 | 0.70 | CNR2 (1.00) | CNR2CNR1CA12CA1CA2 | |
| SCHEMBL9527047 | 0.69 | BRD4 (0.57) | BRD4BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2957560-A1 | PYRIDAZINE DERIVATIVES USEFUL AS CANNABINOID-2 AGONISTS | ALLERGAN, INC. (US) | 2015-12-23 | — | — | EP | disclosed |
| EP-2534137-B1 | PYRIDAZINE DERIVATIVES USEFUL AS CANNABINOID-2 AGONISTS | ALLERGAN INC (US) | 2015-09-16 | — | — | EP | disclosed |