Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 18/20 | 0.79 |
| ▸ | SIRT1 | Q96EB6 | 15/20 | 0.79 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229476 | 0.88 | ALDH1A1 (0.68) | SIRT2SIRT1 | |
| Hydrochloric Acid SCHEMBL1706807 | 0.88 | SIRT2 (1.00) | SIRT2SIRT1 | |
| Hydrochloric Acid SCHEMBL1707574 | 0.88 | SIRT2 (0.78) | SIRT2SIRT1SIRT3 | |
| SCHEMBL17826582 | 0.87 | ALDH1A1 (0.64) | SIRT2SIRT1 | |
| Hydrochloric Acid SCHEMBL1707575 | 0.87 | SIRT2 (0.80) | SIRT2SIRT1SIRT3 | |
| Hydrochloric Acid SCHEMBL1708333 | 0.86 | SIRT2 (0.78) | SIRT2SIRT1SIRT3 | |
| Hydrochloric Acid SCHEMBL1707948 | 0.86 | SIRT2 (0.82) | SIRT2SIRT1SIRT3 | |
| Hydrochloric Acid SCHEMBL1706648 | 0.85 | SIRT2 (0.81) | SIRT2SIRT1SIRT3 | |
| Hydrochloric Acid SCHEMBL1707513 | 0.82 | SIRT2 (0.83) | SIRT2SIRT1SIRT3 | |
| Hydrochloric Acid SCHEMBL1707443 | 0.82 | SIRT2 (0.98) | SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440522-A2 | AROYLTHIOUREA AND ARYLTHIOCARBONYLUREA DERIVATIVES | University Court of The University of Dundee (GB) | 2012-04-18 | — | — | EP | disclosed |