Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | WNT3 | P56703 | 1/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17075716 | 1.00 | MAPT (0.58) | MAPTHTR1AHTR7L3MBTL1ALDH1A1 | |
| SCHEMBL15915182 | 0.80 | MAPT (0.87) | MAPTHTR1AHTR7L3MBTL1ALDH1A1 | |
| SCHEMBL15916996 | 0.78 | MAPT (0.68) | MAPTHTR1AHTR7L3MBTL1ALDH1A1 | |
| SCHEMBL15916994 | 0.78 | MAPT (0.68) | MAPTHTR1AHTR7L3MBTL1ALDH1A1 | |
| SCHEMBL15916457 | 0.76 | MAPT (0.74) | MAPTHTR1AHTR7L3MBTL1ALDH1A1 | |
| SCHEMBL15916455 | 0.76 | MAPT (0.74) | MAPTHTR1AHTR7L3MBTL1ALDH1A1 | |
| SCHEMBL2190597 | 0.75 | CA12 (0.32) | ALDH1A1 | |
| SCHEMBL15934259 | 0.75 | MAPT (0.59) | MAPTHTR1AHTR7L3MBTL1ALDH1A1 | |
| SCHEMBL15915230 | 0.74 | MAPT (1.00) | MAPTHTR1AHTR7L3MBTL1ALDH1A1 | |
| SCHEMBL15915579 | 0.74 | MAPT (0.74) | MAPTHTR1AHTR7L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884878-B2 | FLAP modulators | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-06 | — | — | US | disclosed |
| US-20150259357-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259357-A1 | FLAP MODULATORS | PGF, FEN1, TBXA2R | MAPT 4867/4885HTR1A 1244/4885HTR7 3440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.