Sugi Predict

Sugi Predict / Compounds / SCHEMBL1707698

SCHEMBL1707698

SCHEMBL1707698

COc1ccc(OC)c(Nc2ncc(Br)c(Nc3ccccc3NS(C)(=O)=O)n2)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTK2 Q05397 3/20 0.64
▸ ZAP70 P43403 2/20 0.64
▸ EGFR P00533 11/20 0.63
▸ IGF1R P08069 2/20 0.54
▸ ULK1 O75385 2/20 0.53
▸ MET P08581 2/20 0.50
▸ ALK Q9UM73 2/20 0.50
▸ GLO1 Q04760 1/20 0.50
▸ LRRK2 Q5S007 1/20 0.50
▸ CDC7 O00311 1/20 0.50
▸ PLK4 O00444 1/20 0.50
▸ CHEK1 O14757 1/20 0.50
▸ AURKA O14965 1/20 0.50
▸ DCLK1 O15075 1/20 0.50
▸ PDPK1 O15530 1/20 0.50
▸ DAPK3 O43293 1/20 0.50
▸ JAK2 O60674 1/20 0.50
▸ ROCK2 O75116 1/20 0.50
▸ PRKD3 O94806 1/20 0.50
▸ MAP4K4 O95819 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1707782 0.94 ZAP70 (0.59) PTK2ZAP70EGFRIGF1RULK1
SCHEMBL1707654 0.92 ZAP70 (0.73) PTK2ZAP70EGFRMETALK
SCHEMBL9911241 0.90 EGFR (0.69) PTK2ZAP70EGFRIGF1RULK1
SCHEMBL9911243 0.90 ZAP70 (0.55) PTK2ZAP70EGFRIGF1RULK1
SCHEMBL1707870 0.89 EGFR (0.69) PTK2ZAP70EGFRULK1MET
Hydrochloric Acid SCHEMBL1708532 0.89 EGFR (0.68) PTK2ZAP70EGFRIGF1RULK1
SCHEMBL1708502 0.88 GLO1 (0.65) PTK2ZAP70EGFRMETALK
SCHEMBL9911236 0.88 EGFR (0.64) PTK2EGFRMETALKLRRK2
Hydrochloric Acid SCHEMBL1707842 0.87 EGFR (0.63) PTK2EGFRMETALKLRRK2
SCHEMBL1707723 0.86 ZAP70 (0.53) PTK2ZAP70EGFRIGF1RULK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120142667-A1 PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS CELLZOME LIMITED (GB) 2012-06-07 — — US claimed
EP-2440534-A2 PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS Cellzome Limited (GB) 2012-04-18 — — EP claimed
WO-2010142766-A2 PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS CELLZOME LIMITED (GB) 2010-12-16 — — WO claimed
US-20120142667-A1 PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS CELLZOME LIMITED (GB) 2012-06-07 — — US disclosed
US-20120142667-A1 PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS CELLZOME LIMITED (GB) 2012-06-07 — — US disclosed
US-20120142667-A1 PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS CELLZOME LIMITED (GB) 2012-06-07 — — US disclosed
EP-2440534-A2 PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS Cellzome Limited (GB) 2012-04-18 — — EP disclosed
WO-2010142766-A2 PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS CELLZOME LIMITED (GB) 2010-12-16 — — WO disclosed
WO-2010142766-A2 PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS CELLZOME LIMITED (GB) 2010-12-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120142667-A1 PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS ZAP70, LCK, DPY30 PTK2 1584/4885ZAP70 1/4885EGFR 3420/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.