Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707914 | 0.91 | MAPT (0.33) | KDM4CMAPT | |
| SCHEMBL1708200 | 0.90 | TYK2 (0.34) | JAK2JAK1TYK2JAK3KDM4C | |
| SCHEMBL1707739 | 0.87 | — | — | |
| SCHEMBL1708193 | 0.87 | — | — | |
| SCHEMBL1708575 | 0.87 | KDM4E (0.31) | MAPT | |
| SCHEMBL1707820 | 0.86 | KDM4C (0.30) | KDM4C | |
| SCHEMBL1707801 | 0.85 | — | — | |
| SCHEMBL1707912 | 0.85 | IDO1 (0.30) | — | |
| SCHEMBL3721484 | 0.85 | PPARG (0.40) | KDM4C | |
| SCHEMBL1708263 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |