Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 13/20 | 0.34 |
| ▸ | JAK1 | P23458 | 12/20 | 0.34 |
| ▸ | JAK2 | O60674 | 8/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.30 |
| ▸ | KDM6B | O15054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707746 | 0.90 | JAK2 (0.31) | TYK2JAK1JAK2JAK3KDM4C | |
| SCHEMBL1707912 | 0.89 | IDO1 (0.30) | — | |
| SCHEMBL1707914 | 0.87 | MAPT (0.33) | KDM4C | |
| SCHEMBL1707801 | 0.87 | — | — | |
| SCHEMBL1708214 | 0.86 | KCNK3 (0.30) | — | |
| SCHEMBL1708574 | 0.86 | HDAC1 (0.30) | — | |
| SCHEMBL1707820 | 0.86 | KDM4C (0.30) | KDM4C | |
| SCHEMBL1708311 | 0.86 | HDAC1 (0.30) | — | |
| SCHEMBL1708527 | 0.86 | HDAC1 (0.30) | — | |
| SCHEMBL10011262 | 0.85 | PPARD (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |