Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17087744 | 0.88 | FAAH (0.65) | FAAHHIF1AMAPTPOLBHDAC3 | |
| SCHEMBL19457796 | 0.87 | FAAH (0.64) | FAAHHIF1AMAPTPOLBHDAC3 | |
| SCHEMBL17079298 | 0.87 | FAAH (0.60) | FAAHHIF1AMAPTPOLBHDAC3 | |
| SCHEMBL17079294 | 0.86 | FAAH (0.59) | FAAHHIF1AMAPTPOLBHDAC3 | |
| SCHEMBL17079290 | 0.86 | FAAH (0.59) | FAAHHIF1AMAPTPOLBHDAC3 | |
| SCHEMBL18355988 | 0.86 | FAAH (0.59) | FAAHHIF1AMAPTPOLBHDAC3 | |
| SCHEMBL17087743 | 0.86 | FAAH (0.59) | FAAHHIF1AMAPTPOLBHDAC3 | |
| SCHEMBL17087748 | 0.86 | FAAH (0.59) | FAAHHIF1AMAPTPOLBHDAC3 | |
| SCHEMBL17087740 | 0.86 | FAAH (0.59) | FAAHHIF1AMAPTPOLBHDAC3 | |
| SCHEMBL17079323 | 0.84 | FAAH (0.60) | FAAHHIF1AMAPTPOLBHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116501-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | Proteostasis Therapeutics, Inc. (US) | 2017-01-18 | — | — | EP | claimed |
| WO-2015138909-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2015-09-17 | — | — | WO | claimed |
| EP-3116501-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | Proteostasis Therapeutics, Inc. (US) | 2017-01-18 | — | — | EP | disclosed |
| WO-2015138909-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2015-09-17 | — | — | WO | disclosed |