Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 8/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 8/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PPARD | Q03181 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3502661 | 1.00 | LTB4R (0.39) | LTB4RLTB4R2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL204322 | 0.84 | LTB4R (0.40) | LTB4RLTB4R2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL17431399 | 0.84 | LTB4R (0.40) | LTB4RLTB4R2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL205688 | 0.84 | LTB4R (0.40) | LTB4RLTB4R2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL205181 | 0.82 | LTB4R (0.50) | LTB4RLTB4R2PTGS1PTGS2PPARG | |
| SCHEMBL5788067 | 0.75 | PPARG (0.51) | LTB4RLTB4R2PPARGPPARDFFAR1 | |
| SCHEMBL17431441 | 0.73 | LTB4R (0.34) | LTB4RLTB4R2PTGS1PTGS2ALDH1A1 | |
| SCHEMBL1707872 | 0.72 | CHRNB4 (0.36) | LTB4RLTB4R2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL2729054 | 0.72 | GAA (0.36) | LTB4RLTB4R2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL7179171 | 0.72 | ESR1 (0.39) | LTB4RLTB4R2CHRNB4CHRNA3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |